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ROCK-activated vitreoretinal diseases. ROCK activation is involved in the pathology of retinal vitreous diseases such as diabetic retinopathy, age-related macular degeneration, and PVR, termed as “ROCK-activated diseases.” In each disease, the Rho-ROCK signaling pathway is activated by various cytokines, implicating ROCK in various pathology. Therefore, ROCK is a potential therapeutic target for these vitreoretinal diseases.
