Figure 6.

Biological determinants of niche restriction in C. burnetii. Nutritional and physicochemical variables determined to impact C. burnetii replication and biochemical pathways and enzymatic reactions with documented involvement in these processes are depicted. C. burnetii can utilize both amino acids and glucose, the latter likely transported by a proton-driven glucose transporter encoded by CBU0265. The cytochrome bd terminal oxidase is predicted to allow C. burnetii respiration in a microaerobic environment. The subcellular localization of the C. burnetii CA (CBU0139), possibly involved in CO₂-dependent regulation of C. burnetii cytoplasmic pH, has not been determined. CM, cytoplasmic membrane; CCV, Coxiella Containing Vacuole; CA, carbonic anhydrase; Cyt., cytochrome.