(A) Effect of 3 weeks of treatment with CPA (0.5 mg/kg), ESC (10 mg/kg) and a combination of the two on FT following immobilization stress. Values are expressed as the mean ± SEM (ANOVA followed by Tukey's test). F(4, 45)=10.83; **P<0.05 and #P<0.00001. (B) Effect of treatment with CPA (0.5 mg/kg), ESC (10 mg/kg) and a combination of the two for 3 weeks on the immobility episodes frequency. Each bar represents the mean ± SEM (ANOVA followed by Tukey's test). F(4, 39)=5.037; #P=0.002 and *P<0.05. (C) Effect of treatment with CPA (0.5 mg/kg), ESC (10 mg/kg) and a combination of the two for 3 weeks on immobility latency. Each bar represents the mean ± SEM (ANOVA followed by Tukey's test). F(4, 43)=41.83; #P=0.0001 and **P<0.001. CPA, chlorpheniramine; ESC, escitalopram; FT, floating time; SEM, standard error of the mean.