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Cell uptake of nanoparticles. Representative Prussian blue staining micrographs show obvious uptake of iron nanoparticles in HepG2 cells transfected with the folate-conjugated superparamagnetic iron oxide nanoparticles (SPIO)-loaded cationic amylose complexed with FAM-conjugated scramble siRNA (FA-CA-SPIO/FAM-RNA), compared with those transfected with CA-SPIO/FAM-RNA without folic acid modification (CA-SPIO/FAM-RNA) and FA-CA-SPIO/FAM-RNA plus FA. Scale bar: 100 nm.
