Figure 2.

Representation of the human ApelinR three-dimensional model complexed with pE13F. The peptide backbone of the ApelinR is in orange while pE13F is in green. The blue dashed circle shows a detailed view of the binding site of pE13F with interactions (square dashed boxes) between basics residues of pE13F (Arg², Arg⁴, and Lys⁸, in green) and acidic residues of ApelinR (Asp⁹⁴, Glu¹⁷⁴, and Asp²⁸⁴, in orange). The green dashed circle shows a detailed view of the hydrophobic cavity within ApelinR in which the C-terminal Phe of pE13F (Phe¹³, in green) interacts with aromatic residues of ApelinR (Phe²⁵⁷ and Trp²⁶¹, in orange). Figure adapted from Ref. (19) with permission from the copyright holders.