. Author manuscript; available in PMC: 2017 May 31.

Published in final edited form as: Am J Ophthalmol. 2013 Mar 14;155(6):1068–1074.e1. doi: 10.1016/j.ajo.2013.01.019

Table 3.

Multivariate Model-fitting: Complement Factor H Y402H association with Ocular Sarcoidosis

Genotype	Cases (%)	Controls (%)	Additive Model ^a,^b		Recessive Model ^a,^b		Dominant Model ^a,^b
			OR (95% CI)	p - value	OR (95% CI) ^a	p - value	OR (95% CI) ^a	p - value
CC	11 (27)	53 (13)
CT	18 (44)	174 (44)
			3.08 (1.31, 7.24)	0.008^*	7.18 (2.24, 24.97)	0.002^*	2.22 (0.58, 8.44)	0.217
TT	12 (29)	166 (42)

Abbreviations: OR, Odds Ratio; CI, Confidence Interval

Analyses for model-based Odds Ratios were adjusted by the following covariates: Sex, Race, and CFH*Race interaction.

Model-based P-values are derived from the Likelihood Ratio test which compares the Full model to a model which only includes the adjusting factors and thereby tests if the CFH Genotype is a predictor for susceptibility in a given model.

= p < 0.0167 (Bonferroni- corrected significance level = 0.05/3 for 3 model specific tests)

C = Risk allele.

CC = Homozygous variant (2 risk alleles).

CT = Heterozygous variant (1 risk allele).

TT = Homozygous wildtype (No risk alleles).