. Author manuscript; available in PMC: 2018 May 1.

Published in final edited form as: DNA Repair (Amst). 2017 Mar 21;53:4–14. doi: 10.1016/j.dnarep.2017.03.003

Table 1.

A3B-induced CAN1 mutation and trp1-289 reversion rates.

Genotype	A3B	CAN1 mutation rate X 10⁻⁷ (95% confidence intervals)	trp1-289 reversion rate X 10⁻⁷ (95% confidence intervals)
UNG1	Yes	100 (60–150)	7 (3–20)
UNG1	No	2 (1–3)	1 (0.4–1)
Δung1	Yes	500 (430–620) ^*	2100 (1700–2700) ^*
Δung1	No	6 (5–10)	11 (9–13)
Δung1, Δrnh1	Yes	500 (160–670) ^*	1500 (1100–6300) ^*
Δung1, Δrnh1	No	5 (4–9)	11 (6–17)
Δung1, Δrnh35	Yes	540 (380–690) ^*	1800 (900–2100) ^*
Δung1, Δrnh35	No	10 (6–22)	10 (8–20)
Δung1, Δrnh1, Δrnh35	Yes	910 (550–2400) ^#	3900 (3200–12000) ^#
Δung1, Δrnh1, Δrnh35	No	10 (7–11)	11 (9–13)
Δapn1	Yes	120 (100–190)	21 (16–32) ^*
Δapn1	No	7 (6–12)	3 (2–9)
Δapn2	Yes	150 (150–190) ^*	19 (15–22) ^*
Δapn2	No	4 (3–7)	1 (0.4 – 2)
Δapn1, Δapn2	Yes	120 (60–190)	21 (15–40) ^*
Δapn1, Δapn2	No	9 (5–13)	2 (0.5–2)
Δmms2	Yes	190 (170–210) ^*	29 (24–34) ^*
Δmms2	No	16 (12–23)	4 (3–6)
Δrad51	Yes	410 (270–980) ^*	103 (61–176) ^*
Δrad51	No	37 (29–50)	10 (8–19)
Δapn1, Δrad51	Yes	680 (450–1000) ^*	370 (210–890) ^*
Δapn1, Δrad51	No	100 (100–290)	39 (22–51)
Δmms2, Δapn1	Yes	320 (190–420) ^*	125 (80–160) ^*
Δmms2, Δapn1	No	63 (40–140)	19 (10–75)

Denotes rates significantly higher than UNG1 strain with A3B (P<0.05)

Denotes rates significantly higher than Δung1 RNH1 RNH35 strain with A3B (P<0.05)