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. 2017 May 31;4:68. doi: 10.3389/fmed.2017.00068

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Copyright © 2017 Rao, Ge and Sriramarao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multistep paradigm of eosinophil trafficking under conditions of flow. Eosinophil rolling along the inflamed and activated vascular endothelium is supported by eosinophil-expressed L-selectin, α4β1, and P-selectin glycoprotein ligand-1 (PSGL-1) and endothelial-expressed vascular cell adhesion molecule (VCAM)-1 and P-selectin. Activation-dependent stable adhesion of eosinophils to the vascular endothelium is mediated by α4β1/VCAM-1 and αMβ2/intercellular adhesion molecule (ICAM)-1 interactions. Extravasation or trans-endothelial migration is under the control of chemokines (eotaxins and other chemokines).