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. 2017 May 31;4:68. doi: 10.3389/fmed.2017.00068

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Copyright © 2017 Rao, Ge and Sriramarao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gal-3-mediated eosinophil–endothelial interactions during cell trafficking. Gal-3 is present on the surface of eosinophils bound to α4. (A) In addition to α4β1/vascular cell adhesion molecule (VCAM)-1 interactions, eosinophil-expressed Gal-3 can independently interact with EC-expressed VCAM-1. (B) Eosinophil-expressed α4 can interact with EC-expressed Gal-3. (C) Eosinophil-expressed Gal-3 can bind to EC-expressed Gal-3.