Table 2.

Multivariable Survival Analysis for 366 Patients Who Underwent Lymphadenectomy

Variable	Model 1		Model 2		Model 3
	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value
Carbohydrate antigen 19-9*	1.16 (1.08–1.24)	<0.001	1.15 (1.07–1.23)	<0.001	1.14 (1.07–1.22)	<0.001
AJCC T stage
T1	Ref		Ref		Ref
T2a–T2b	1.48 (0.91–2.41)	0.11	1.45 (0.89–2.36)	0.13	1.46 (0.90–2.37)	0.12
T3–T4	1.92 (1.14–3.23)	0.014	1.96 (1.16–3.29)	0.011	1.97 (1.18–3.29)	0.009
AJCC N stage
N0	Ref
N1	1.36 (1.05–1.75)	0.019
Lymph node ratio
0%			Ref
1% to 25%			1.12 (0.77–1.62)	0.56
25% to 50%			1.39 (1.00–1.94)	0.049
>50%			1.76 (1.17–2.65)	0.007
Log odds of positive lymph node
Less than −2					Ref
−1.99 to −0.9					1.34 (0.99–1.85)	0.06
−0.89 to 1.5					1.67 (1.16–2.40)	0.006
>1.5					2.80 (1.44–5.43)	0.002
C-index	0.626		0.630		0.640

^*Hazard ratio and CIs estimated for the natural logarithm of the carbohydrate antigen 19-9 serum level.

AJCC, American Joint Committee on Cancer; HR, hazard ratio; Ref, reference.