Table 1.
Association of maternal and neonatal characteristics in patients who used or did not use ranitidine in a Brazilian NICU, 2014–2015
| Variable | Not exposed to Ranitidine | Exposed to Ranitidine | p-value |
|---|---|---|---|
| n = 185 | n = 115 | ||
| Maternal and prenatal care information | |||
| Age mother, mean (SD) | 25.0 (7.2) | 24.5 (6.8) | 0.53a |
| > 6 visits prenatal care, n (%) | 56 (30.3) | 34 (29.6) | 0.89b |
| Hypertension, n (%) | 16 (8.6) | 13 (11.3) | 0.45b |
| Diabetes Mellitus, n (%) | 1 (0.5) | 1 (0.9) | 0.73b |
| Gestational diabetes, n (%) | 1 (0.5) | 1 (0.9) | 0.73b |
| Caesarean section delivery, n (%) | 95 (51.4) | 47 (40.9) | 0.08b |
| Characteristics of the neonates | |||
| Male, n (%) | 88 (47.6) | 60 (52.2) | 0.44b |
| Twins, n (%) | 31 (16.8) | 19 (16.5) | 0.95b |
| Gestational age, median (IQR) | 32 (31–34) | 32 (30–33) | 0.26c |
| Birth weight (g), median (IQR) | 1474 (1163–1863) | 1410 (1150–1810) | 0.29c |
| Apgar score at 1 min, median (IQR) | 7 (5–8) | 7 (5–8) | 0.24c |
| Apgar score at 5 min, median (IQR) | 9 (8–9) | 8 (8–9) | 0.16c |
| Devices used by the neonate | |||
| Duration of mechanical ventilation (d), mean (SD) | 2.0 (3.3) | 5.5 (7.2) | <0.001a |
| Duration of umbilical catheter (d), mean (SD) | 1.9 (2.6) | 2.8 (2.7) | 0.007a |
| Duration of central catheter peripherally inserted (d), mean (SD) | 4.0 (6.0) | 7.2 (8.2) | <0.001a |
| Duration of orogastric tube (d), mean (SD) | 19.9 (15.3) | 11.9 (9.3) | <0.001a |
| Duration of parenteral nutrition (d), mean (SD) | 3.0 (4.3) | 5.9 (5.4) | <0.001a |
d days, SD standard deviation, IQR interquartile range
aT-Student test
bChi-Square test
cMann-Whitney U test