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. Author manuscript; available in PMC: 2018 May 30.
Published in final edited form as: Eur J Pharm Sci. 2017 Feb 24;103:52–59. doi: 10.1016/j.ejps.2017.02.011

Fig 5. Inhibitory effects of model-predicted inhibitors on MRP3-mediated E217G transport.

Fig 5

MRP3 vesicles were co-incubated with model-predicted inhibitors (100 μM) or MK-571 (50 μM) and [3H]-E217G (10 μM) for 5 min at 37 °C. Values are expressed as percentage of vehicle control (DMSO) (mean ± SEM; n=3 in triplicate). Compounds that caused a decrease in [3H]-E217G uptake that was not statistically different from the model threshold of 50% inhibition are indicated by #, p < 0.05.