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. Author manuscript; available in PMC: 2018 May 30.
Published in final edited form as: Eur J Pharm Sci. 2017 Feb 24;103:52–59. doi: 10.1016/j.ejps.2017.02.011

Fig 6. Inhibitory potency of dronedarone, fidaxomicin, and suramin on MRP3-mediated E217G transport.

Fig 6

IC50values were determined at concentrations of 0.1 to 100 μM for dronedarone (A), fidaxomicin (B), and suramin (C) on MRP3-mediated [3H]-E217Gtransport (10 μM; 5-min incubation). Values are expressed as percentage of vehicle control; each value represents the mean ± SD. IC50 values (mean ± SEM; n=3 in triplicate) were calculated using non-linear least square regression for dronedarone (47.44±4.41 μM), fidaxomicin (1.83±0.46 μM), and suramin (3.33±0.41 μM).