Table 1.
Selected demographic and clinical characteristics of 843ADNI participants
| CN (N = 199) |
SMC (N = 85) |
EMCI (N = 239) |
LMCI (N = 207) |
AD (N = 113) |
P-value | |
|---|---|---|---|---|---|---|
| Age (years) | 74.4 (5.79) | 72.0(5.48) | 71.4(7.30) | 72.4(7.62) | 75.2 (8.19) | p < 0.001 |
| Women* | 96(48%) | 50(59%) | 102(43%) | 83(40%) | 45(40%) | 0.002* |
| Education (years) | 16.2 (2.82) | 16(2.79) | 16.2(2.84) | 16.4(2.53) | 16.4(2.56) | 0.764 |
| APOE e4 allele present | 47(24%) | 31(36%) | 99 (41%) | 112(54%) | 74 (65%) | p < 0.001 |
| CDR-SOB | 0.04(0.14) | 0.08(0.18) | 1.27(0.77) | 1.65(0.94) | 4.53 (1.70) | p < 0.001 |
| Mini mental status examination | 29.1(1.18) | 29.0(1.2) | 28.3(1.62) | 27.5(1.75) | 23.1 (2.05) | p < 0.001 |
| Logical memory immediate recall |
14.42(3.00) | 14.44(3.34) | 11.09(2.68) | 7.18(3.06) | 4.15 (2.70) | p < 0.001 |
| Logical memory delayed recall |
13.34(3.13) | 13.29(3.31) | 8.97(1.73) | 3.94 (2.7) | 1.52 (1.80) | p < 0.001 |
| t-tau/Aβ1-42Ratio (i.e., QT for GWAS) |
0.40 (0.27) | 0.37(0.24) | 0.50(0.45) | 0.70(0.47) | 0.98 (0.49) | p < 0.001 |
AD Alzheimer’s disease, ADNI Alzheimer’s Disease Neuroimaging Initiative, CDR–SOB clinical dementia rating–sum of boxes, CN cognitively normal, SMC significant memory concern, EMCI early mild cognitive impairment, LMCI late mild cognitive impairment. Number (%) or mean (s.d.) was shown in each entry. P-values were assessed due to significant differences between diagnosis groups, which computed using one-way ANOVA (*except for gender using chi-square test)