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. 2017 May 30;16:97. doi: 10.1186/s12943-017-0662-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Antitumor activity of the combination of PTX, bevacizumab and MEK162 in MNHOC124 PDX model. Xenograft MNHOC124 was transplanted subcutaneously and when tumor masses reached 100-150mg, mice were randomized to receive vehicle (CTR,-♦-), or bevacizumab and MEK162 (BEV/MEK,-■-), paclitaxel and MEK162 (PTX/MEK,-▲-), paclitaxel and bevacizumab (PTX/BEV, -●-), or paclitaxel and bevacizumab and MEK162 (PTX/BEV/MEK,-x-). Data are the mean ± SE of tumor masses, as described in Materials and Methods; each group consisted of 8-10 mice