TABLE 1.

WB and Serum Kinetic Parameters

Parameter	10 mg	20 mg	50 mg	Overall mean ± SD
WB biologic half-life (h)	143 (119–257)	222 (165–365)	236 (211–450)	225 ± 82
WB effective half-life (h)	51 (47–60)	58 (53–65)	59 (57–67)	57 ± 5
Serum A1 (%/L)	8 (5–14)	12 (6–23)	13 (9–16)	12 ± 5
Serum α effective half-life (h)	3.1 (1.2–5.7)	5.0 (1.9–8.0)	6.3 (2.2–8.9)	5 ± 3
Serum A2 (%/L)	18 (15–27)	18 (14–29)	18 (13–27)	19 ± 5
Serum β effective half-life (h)	19 (17–27)	22 (19–27)	28 (25–32)	24 ± 5

Data are median, with range in parentheses.