Table 5.

The association of IL-8 -251 T > A polymorphism with the risk of GC in different ethnicities

Ethnicity	TT / total GC (%) TT / total controls (%) OR [95% CI]	TA / total GC (%) TA / total controls (%) OR [95% CI]	AA / total GC (%) AA / total controls (%) OR [95% CI]	A* / total GC (%) A* / total controls (%) OR [95% CI]
This study (Korean)	81/283 (28.62%) 70/176 (39.77%) 0.60 [0.40, 0.90]	168/283(59.36%) 89/176 (50.57%) 1.43 [0.98, 2.09]	34/283(12.01%) 17/176(9.66%) 1.27 [0.70, 2.31]	202/283(71.38%) 106/176 (60.23%) 1.66 [1.11, 2.47]
Korean [16, 17]	180/487(36.96%) 244/528(46.21%) 0.68 [0.53, 0.88]	241/487(49.49%) 234/528(44.32%) 1.23 [0.96, 1.57]	66/487(13.55%) 50/528(9.47%) 1.50 [1.02, 2.20]	307/487(63.04%) 284/528 (53.79%) 1.46 [1.14, 1.88]
Japanese [13–15]	337/789(42.71%) 485/964(50.31%) 0.74 [0.61, 0.89]	375/789(47.53%) 397/964(41.18%) 1.29 [1.07, 1.56]	77/789(9.76%) 82/964(8.51%) 1.16 [0.84, 1.62]	452/789(57.29%) 479/964(49.69%) 1.36 [1.12, 1.64]
Chinese [18–20]	329/926(35.53%) 270/814(33.17%) 1.11 [0.91, 1.35]	425/926(45.90%) 406/814(49.88%) 0.85 [0.71, 1.03]	172/926(18.57%) 138/814(16.95%) 1.12 [0.87, 1.43]	597/926(64.47%) 544/814(66.83%) 0.90 [0.74, 1.10]
Caucasian [21–23]	224/732(30.60%) 381/1328(28.69%) 1.10 [0.90, 1.34]	365/732(49.86%) 669/1328(50.38%) 0.98 [0.82, 1.17]	143/732(19.54%) 278/1328(20.93%) 0.92 [0.73, 1.15]	508/732(69.40%) 947/1328(71.31%) 0.91 [0.75, 1.11]
Combined Korean and Japanese	598/1559(38.36%) 799/1668(47.90%) 0.70 [0.61, 0.81]	784/1559(50.29%) 720/1668(43.17%) 1.29 [1.12, 1.48]	177/1559(11.35%) 149/1668(8.93%) 1.29 [1.02, 1.62]	961/1559(61.64%) 869/1668(52.10%) 1.42 [1.24, 1.64]

A*: A allele carriers (T/A + A/A)

The combined Korean and Japanese populations showed significant GC risk in IL-8 -251 T/A, A/A, and A allele carriers