Fig. 3.

Associations between genotype and phenotype for the top-scoring (a) three-factor and (b) two-factor models on the Crush-MDR Pareto front. Each cell shows one genotype combination and the average phenotypic difference from the mean for subjects with those genotypes. Wider bars indicate a larger number of subjects with those genotypes. Dark gray cells indicate genotypes associated with higher-than-average hippocampal volume (HV). Light gray cells indicate lower-than-average HV, and white cells represent genotypes with no subjects. Genotypes are coded as 0/1/2 according to the number of copies of the major allele