Table 4.
Down-regulated genes in rats fed with SPI diet*
| Category and Gene Name | Probe Set GB Accession No. | Fold Change | P value |
| Cell adhesion | |||
| Embigin | AJ009698 | -5.13 | 0.001 |
| Cell Cycle/growth control | |||
| FGF receptor activating protein 1 | U57715 | -5.59 | 0.002 |
| BEST5 protein | Y07704 | -2.37 | 0.003 |
| Peptide tyrosine-tyrosine (YY) | M17523 | -3.91 | 0.002 |
| Glucagon gene | K02813 | -6.58 | 0.002 |
| Epithelial membrane protein-1 | Z54212 | -3.47 | 0.017 |
| Neu oncogene | X03362 | -1.58 | 0.05 |
| Defense/immunity protein | |||
| Beta defensin-1 | AF068860 | -42.16 | 0.001 |
| AF093536 | -10.2 | 0 | |
| Detoxification/antioxidation | |||
| Glutathione S-transferase | J02810 | -7.14 | 0 |
| Glutathione S-transferase Yb | X04229 | -11.71 | 0.001 |
| Glutathione S-transferase, alpha 1 | K01932 | -4.18 | 0.004 |
| Glutathione S-transferase Yc1 | S72505 | -5.23 | 0.001 |
| Glutathione S-transferase Yc2 | S72506 | -5.27 | 0.012 |
| S82820 | -3.45 | 0.006 | |
| Cytochrome P450 4F4 (CYP4F4) | U39206 | -6.52 | 0.002 |
| Cytochrome P450CMF1b | J02869 | -4.12 | 0.002 |
| Cytochrome P450 (CYP4F1) | M94548 | -2.88 | 0.002 |
| 1-Cys peroxiredoxin | Y17295 | -2.55 | 0.002 |
| Metallothionein | M11794 | -2.92 | 0.006 |
| D-amino-acid oxidase | AB003400 | -5.42 | 0 |
| Peroxiredoxin 6 | AF014009 | -3.07 | 0.008 |
| Phenylalanine hydroxylase | M12337 | -10.99 | 0.001 |
| Metabolism | |||
| Dipeptidase | L07315 | -3.08 | 0.001 |
| Meprin beta-subunit | M88601 | -3.27 | 0.001 |
| Disintegrin and metalloprotease domain 7 | X66140 | -14.03 | 0 |
| Ligand binding/carrier | |||
| Carnitine transporter | AB017260 | -3.81 | 0.003 |
| Chloride channel (ClC-2) | AF005720 | -3.26 | 0.001 |
| Putative potassium channel | AF022819 | -2.69 | 0.001 |
| Mitochondrial dicarboxylate carrier | AJ223355 | -2.54 | 0.01 |
| Aquaporin 3 | D17695 | -4.13 | 0 |
| Intestinal fatty acid binding protein | K01180 | -4.43 | 0.005 |
| Na_H_Exchanger | L11236 | -4.47 | 0.002 |
| H+, K+-ATPase | M90398 | -2.52 | 0.001 |
| Carbonic anhydrase IV | S68245 | -4.28 | 0.005 |
| Sodium transporter | X59677 | -3.4 | 0 |
| Phosphatidylethanolamine binding protein | X75253 | -2.69 | 0 |
| Signal transduction | |||
| B7 antigen | X76697 | -170.95 | 0.002 |
| HCNP | E05646 | -3.38 | 0 |
| Itmap1 | AF022147 | -7.97 | 0.005 |
| Guanylate cyclase activator 2A | M95493 | -3.28 | 0.006 |
| Sgk | L01624 | -2.76 | 0 |
| Stress response/apoptosis | |||
| Prostaglandin D synthetase | J04488 | -45.8 | 0.01 |
| Structure proteins | |||
| Muc3 | U76551 | -3.56 | 0.01 |
| Intestinal mucin | M76740 | -3.31 | 0.006 |
| Mucin-like protein | M81920 | -3 | 0 |
| Plasmolipin | Z49858 | -2.92 | 0.003 |
| Transcription factor/regulator | |||
| Testis specific X-linked gene | X99797 | -6.91 | 0.003 |
| Others | |||
| Arginase II | U90887 | -3.22 | 0 |
| 3-phosphoglycerate dehydrogenase | X97772 | -4.15 | 0.017 |
| Aldehyde dehydrogenase family 1 | AF001898 | -3.93 | 0.004 |
*Changes in gene expression were determined by t-test (DMT), comparative analysis (MAS 5.0), and SAM (Stanford). Gene expression profiles from CAS animals were used as control. P value and fold-change are based on the DMT analysis; whereas genes listed above met all of the analytical criteria as described in Methods.