Table V.
KEGG pathway enrichment analysis of differentially expressed microRNA target genes (Top 15).
| KEGG ID | KEGG term | Count | FDR | Genes |
|---|---|---|---|---|
| hsa04510 | Focal adhesion | 19 | 1.07E-08 | COL4A4, IGF1, PPP1R12A, ROCK2, CCND2, BCAR1, COL4A5, RAP1A, THBS1, MYLK2, PRKCA, CRK, PIK3R3, CAPN2, THBS2, VASP, COL5A1, COL11A1, FN1 |
| hsa05200 | Pathways in cancer | 23 | 2.49E-08 | COL4A4, AXIN2, KITLG, FOS, FZD6, TGFA, IGF1, GLI3, COL4A5, E2F1, TPM3, PRKCA, CRK, PIK3R3, CDKN1A, TGFB1, BAX, GLI2, TP53, PAX8, TRAF1, FN1, EGLN2 |
| hsa04060 | Cytokine-cytokine receptor interaction | 20 | 5.88E-08 | INHBB, TNFRSF10D, KITLG, BMPR1A, TNFRSF10B, CNTFR, IL28RA, TNFRSF21, CX3CR1, IFNG, LIFR, TGFB1, IL2RA, NGFR, CCR5, ACVR1B, CXCL12, TNFSF9, TNFSF10, CCR6 |
| hsa05146 | Amoebiasis | 13 | 1.03E-07 | ARG2, COL4A4, GNAL, ADCY1, COL4A5, RAB5B, IFNG, PRKCA, PIK3R3, TGFB1, COL5A1, COL11A1, FN1 |
| hsa04062 | Chemokine signaling pathway | 15 | 2.66E-06 | TIAM1, ADCY1, ROCK2, BCAR1, ADCY9, CX3CR1, RAP1A, CRK, PIK3R3, JAK3, GNG5, CCR5, CXCL12, GNG4, CCR6 |
| hsa05214 | Glioma | 8 | 8.41E-05 | CAMK2D, TGFA, IGF1, E2F1, PRKCA, PIK3R3, CDKN1A, TP53 |
| hsa05144 | Malaria | 4 | 1.01E-04 | IFNG, THBS1, TGFB1, THBS2 |
| hsa04350 | TGF-beta signaling pathway | 4 | 1.01E-04 | IFNG, THBS1, TGFB1, THBS2 |
| hsa04670 | Leukocyte transendothelial migration | 10 | 1.06E-04 | JAM3, ROCK2, BCAR1, ESAM, RAP1A, PRKCA, PIK3R3, CYBB, VASP, CXCL12 |
| hsa04115 | p53 signaling pathway | 8 | 1.18E-04 | TNFRSF10B, IGF1, CCND2, THBS1, SERPINE1, CDKN1A, BAX, TP53 |
| hsa04971 | Gastric acid secretion | 8 | 1.36E-04 | KCNK10, CAMK2D, ADCY1, ADCY9, MYLK2, PRKCA, ITPR1, SSTR2 |
| hsa04310 | Wnt signaling pathway | 11 | 1.42E-04 | NLK, CAMK2D, AXIN2, FZD6, ROCK2, CCND2, PRKCA, DAAM2, TBL1X, TP53, DAAM1 |
| hsa04722 | Neurotrophin signaling pathway | 10 | 1.56E-04 | CAMK2D, RAP1A, CRK, PIK3R3, YWHAG, NGFR, BAX, RPS6KA3, TP53, NTRK3 |
| hsa04630 | Jak-STAT signaling pathway | 11 | 1.58E-04 | CNTFR, CCND2, I L28RA, IFNG, LIFR, STAT6, SOCS3, PIK3R3, JAK3, IL2RA, CISH |
| hsa04020 | Calcium signaling pathway | 6 | 1.61E-04 | CAMK2D, ADCY1, ADCY9, MYLK2, PRKCA, ITPR1 |
KEGG, Kyoto Encyclopedia of Genes and Genomes; FDR, false discovery rate; TGF, transforming growth factor; STAT, signal transducer and activator of transcription.