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. 2017 May 13;15(5):138. doi: 10.3390/md15050138

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of (-)-4-hydroxysattabacin (4OH-ST, 1) and (-)-sattabacin (2) on melanin contents and cell viability on B16F10 cells. (a) Chemical structures of (-)-4OH-ST (1) and (-)-sattabacin (2); (b) Melanin contents were measured by melanin assay; (c) Cell viability was determined by WST-1 assay. The cells were treated with arbutin at 50 µg/mL, (-)-4OH-ST (1) or (-)-sattabacin (2) at the indicated concentrations for 72 h. Data are presented as the mean ± standard deviation (SD) (n = 3–5).