Figure 1.

Protective effect of rTM on survival of LPS-induced septic model mice. LPS (15 mg/kg) was injected into the peritoneal cavity (LPS group); 3 mg/kg of rTM was administered 30 min prior to or 2 h after the LPS-injection (pre-rTM group or post-rTM group, respectively). Survival of LPS, pre-rTM and post-rTM groups (n=8 mice each) was monitored for up to 3 days. Values are compared between LPS group and pre-rTM group or post-rTM group. **P<0.01. LPS, lipopolysaccharide; rTM, recombinant thrombomodulin.