Table II.
LPE rescued CCL4-induced liver injury by preserving the glutathione antioxidative system.
| Groups | GSH peroxidase (nmol/min/ml) | GSH reductase (nmol/min/ml) |
|---|---|---|
| Normal control | 70.19±3.37c | 233.51±25.18a,b |
| H2O vehicle | 61.42±2.98d | 174.04±27.24d |
| Silymarin | 75.95±5.06a,b | 218.86±20.69b,c |
| Low LPE (20 mg/kg BW) | 82.21±1.32a | 180.20±38.41c,d |
| Middle LPE (100 mg/kg BW) | 68.93±3.02c | 193.03±39.18c |
| High LPE (200 mg/kg BW) | 72.73±7.39b,c | 265.24±48.78a |
Data are presented as mean ± standard deviation (n=8).
a,b,c,d
represent the comparisons among treatments in the same column, with different superscripts indicating significant differences at P<0.05. Mice were injected with CCl4 twice weekly, apart from mice in the normal control group, and subjected to daily gavage-feeding of the same volume of either H2O or silymarin (200 mg/kg BW), or a low level (20 mg/kg BW), middle level (100 mg/kg BW) or high level dose (200 mg/kg BW) of LPE. LPE, litchi pericarp extract; GSH, glutathione; CCl4, carbon tetrachloride; BW, body weight; NC, normal house-keeping control group.