Table 1.

Drug targeting outlook in different fields.

Oncology	Heart, lung and blood diseases
Challenges:	Challenges:
Heterogeneity of targets and diseases	High benefit/risk bar and low ROI
Poor target accessibility	Limited investments and research
Specific paradigms:	Specific paradigms:
Toxic drugs, collateral damage	More benign drugs vs. oncology
Maximal specificity of targeting needed	Systemic effects often welcome
Side effects to target are welcome	Side effects to target unacceptable
Advantages:	Advantages:
Dominant field of drug targeting	Huge medical need (I/R, ARDS)
Side effects are often beneficial	Common mechanisms and targets
Low benefit/risk bar and high ROI	Target accessibility to blood