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. 2017 May 19;9(5):173. doi: 10.3390/toxins9050173

Figure 8.

Figure 8

Cytokine production by peritoneal macrophages in the presence of RI-BoNT/A immune complexes and RBCs. Peritoneal macrophages were cultured in vitro and incubated with RI-BoNT/A bound to the 3-mAb or 4-mAb combinations, alone or in combination with the FP or with the FP and RBCs. The production of IL-10 and TNF-α was measured over time using a luminescence capture assay. Top panels: IL-10 production induced by complexes containing the (a) 3-mAb or (b) 4-mAb. Bottom panels: TNF-α production induced by complexes containing the (c) 3-mAb or (d) 4-mAb. The y-axis in panel (b) is greyed to emphasize that it has a different scale than panels (a,c,d).