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. 2017 Feb 21;18(4):205–213. doi: 10.1080/15384047.2017.1294288

Figure 3.

Figure 3.

Effects of sunitinib treatment on the expression of EMT-associated transcription factors in TNBC tumors. (A) IHC staining for VE-cadherin, Twist1, Snail and Slug. VE-cadherin is upregulated in the sunitinib-treated MDA-MB-231 tumors compared with the placebo-treated MDA-MB-231 tumors. Sunitinib increased Twist1 expression in the MDA-MB-231 tumors, and Twist1 localized to the nucleus in the treatment group. There was no change observed in the MCF-7 groups. Sunitinib did not affect the expression of Snail and Slug in the TNBC MDA-MB-231 tumors and the non-TNBC MCF-7 tumors. (B) Quantification of VE-cadherin expression in the different groups. (C)Quantification of Twist1 expression in the different groups. (D) Quantification of Slug expression in the different groups. The scale bar indicates 100 μm, and the error bar indicates the standard deviation (SD). * P < 0.05, ** P < 0.01, *** P < 0.001.