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The effect of IBET and FOXOi treatment on the protein level of Skp2. (A) BON cells were treated with either DMSO or IBET (0.5uM) for 3 days, followed by Western blotting analysis to detect the protein levels with the indicated antibodies. (B) BON cells were treated with DMSO or FOXOi (100nM) for 3 days, followed by Western blotting with the indicated antibodies. (C) A working model to explain IBET-induced upregulation of p27 protein level via suppressing expression of Skp2.
