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. 2017 Apr 18;13(6):2939–2945. doi: 10.3892/etm.2017.4346

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Copyright: © Kawakita et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Schematic for model of the effects of 15d-PGJ2 alone and in combination with dasatinib in uterine sarcoma cells. (A) No treatment. AKT and MAPK pathways are activated. (B) 15d-PGJ2 inactivates AKT. However, the MAPK pathways are activated. (C) The combination of 15d-PGJ2 with dasatinib suppresses both AKT and MAPK pathways and leads to synergistic antiproliferative effects.