TABLE 3.

AVERAGE ANNUAL UNDERLYING CAUSE OF DEATH FOR DECEDENTS WITH RHEUMATOID ARTHRITIS–INTERSTITIAL LUNG DISEASE AND RHEUMATOID ARTHRITIS ALONE OVER THE ENTIRE STUDY PERIOD

Underlying Cause of Death	RA-ILD: % (SD, %) (n = 10,725)	RA (no ILD): % (SD, %) (n = 151,322)	OR (95% CI)	P Value
Rheumatoid arthritis complications	35.0 (4.1)	20.4 (3.9)	2.1 (2.0–2.2)	<0.0001
Pulmonary diseases
Interstitial lung disease	35.3 (6.4)	—	—	—
Pulmonary embolism	0.3 (0.4)	0.5 (0.1)	0.66 (0.47–0.93)	0.0168
Chronic obstructive lung disease	1.6 (1.3)	2.5 (2.3)	0.68 (0.59–0.79)	<0.0001
Lung cancer	2.1 (0.5)	3.5 (0.3)	0.58 (0.50–0.66)	<0.0001
Cardiac diseases
Acute MI	2.6 (0.9)	7.8 (1.3)	0.31 (0.27–0.34)	<0.0001
Chronic ischemic heart disease	4.0 (0.9)	11.7 (0.7)	0.32 (0.29–0.35)	<0.0001
Congestive heart failure/cardiomyopathy	1.3 (0.5)	3.1 (0.2)	0.43 (0.37–0.51)	<0.0001
Total cardiac diseases	7.9 (1.6)	22.6 (1.7)	0.29 (0.27–0.31)	<0.0001
CVA/stroke	0.9 (0.4)	5.4 (0.4)	0.16 (0.13–0.20)	<0.0001
Infectious diseases
Pneumonia	2.1 (1.2)	4.4 (2.8)	0.44 (0.39–0.51)	<0.0001
Sepsis	0.6 (0.3)	1.8 (0.2)	0.33 (0.26–0.42)	<0.0001
TB	0.08 (0.10)	0.09 (0.04)	0.89 (0.45–1.74)	0.7293
Total infectious diseases	2.7 (1.0)	6.3 (2.7)	0.41 (0.37–0.46)	<0.0001
Other	14.0 (2.4)	38.8 (2.2)	0.25 (0.24–0.28)	<0.0001

Definition of abbreviations: CI = confidence interval; CVA = cerebrovascular accident; ICD = International Classification of Diseases; ILD = interstitial lung disease; MI = myocardial infarction; OR = odds ratio; RA = rheumatoid arthritis; TB = tuberculosis.

ICD-9 and ICD-10 codes used for each of the categories are presented in the Appendix.