Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Feb 25;18(4):237–244. doi: 10.1080/15384047.2017.1294292

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Taylor & Francis Group, LLC

PMC Copyright notice

Figure 4. — Protein expression analysis of the key glycolytic enzymes after inhibition of stat3/c-Myc signaling. (A) The expression of phos-STAT3, c-Myc, LDHA and HK2 were inhibited by STAT3 inhibitor S3I-201. (B) HT-29 cells first treated with IL-6 in advance to activate c-Myc and phos-STAT3 expression. Then glycolytic enzymes protein expression was detected after S3I-201 treatment. (C and D) c-Myc expression was inhibited by Myc inhibitor JQ1 in HIEC, then analyzed the key enzymes expression with JQ1 only or combined with IL-6 respectively. (E) S3I-201 blocked c-Myc and glycolytic enzymes expression within a short time after cells pre-treated IL-6 in 12 hours. (F) A scheme of the mechanism involved in the inflammation-induced metabolic reprogramming.