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. Author manuscript; available in PMC: 2017 May 31.
Published in final edited form as: EC Microbiol. 2016 Oct 18;3(6):597–604.

Table 2.

Summary of Studies Showing HIV Proteins Enhance ROS Production. ↑ indicates induction

HIV ROS Cellular Target Cell type Reference
TAT ↑ Increase NFkB Transcription MAGI-CCR5 Zhang, 2011
TAT ↑ Increase TNF Jurkat T cell & HeLa-tat Westendorp, 1995
TAT ↑ Decrease Mitochondrial SOD Jurkat T cell & HeLa-tat Westendorp, 1995
TAT ↑ Increase Activation-Induced Cell Death (ACID) Jurkat T cell & Primary T cells Gulow, 2005
gp41 ↑ HIV Env-mediated apoptosis CHO & Primary T cells Garg, 2005
Vpr ↑ IL-6 mediated viral reactivation Primary MDM & Ul monocytes Hoshino, 2010