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. 2017 May 15;144(10):1807–1819. doi: 10.1242/dev.141911

Fig. 2.

Fig. 2.

unc-3 mutation causes defects in GABAergic transmission and iAChR clustering in GABAergic neurons. (A) Representative recordings of endogenous IPSCs from body wall muscles of wild-type animals and unc-3(e151) mutants. Red traces are expanded views of time segments under the red bars in the upper traces. (B) The average frequency of endogenous IPSCs recorded from wild type and unc-3(e151) mutants. ***P<0.0001, Student's t-test. (C) Cumulative distribution of amplitudes of endogenous IPSCs recorded from wild type and unc-3(e151) mutants. ***P<0.001; Kolmogorov–Smirnov test. (D) Confocal images showing the dorsal nerve cord of eight animals expressing ACR-12::GFP in GABA neurons for the genotypes indicated. Scale bars: 5 µm. (E) Quantification of the average number of receptor clusters per 85 µm of dorsal nerve cord for the genotypes indicated, normalized to wild type. *P<0.05, ****P<0.0001; ANOVA with Dunnett's multiple comparisons test.