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. 2005 Jan 19;102(5):1725–1730. doi: 10.1073/pnas.0406797102

Fig. 2.

Fig. 2.

Morphine and endogenous opioids modulate excitatory synaptic transmission. (A)(Left) Five consecutive traces of mEPSCs that were recorded from a 3-week-old control neuron. (Right) Similar traces from a morphine-treated neuron. (B)(Left) An averaged trace recorded from a morphine-treated neuron for 15 min (black trace) was compared with a similar averaged trace from a control neuron (gray trace). (Right) The black trace was rescaled to have the same amplitude as the gray trace. Note that morphine changed the time course of mEPSC responses by shortening both the rising and decaying phases. (C–F) Various parameters of mEPSCs were compared among five groups of experiments (all were 3-week-old neurons). Ctl, untreated; Mor, morphine-treated; M+Ctp, morphine plus CTOP; M+Nal, morphine plus naloxone; Nal, naloxone alone. (G–I) Various parameters of mEPSCs were compared between a 1-week-old untreated neuron (open bars) and a morphine-treated neuron (filled bars).