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. 2016 Dec 13;2016(12):CD006519. doi: 10.1002/14651858.CD006519.pub3

Nanulescu 1999.

Methods RCT
Generation of allocation sequence: randomly assigned
Allocation concealment: not reported
Blinding: none
Inclusion of participants in analysis: 88% (rice group, 48/56, 86%; glucose group, 51/57, 89%)
Duration: 12 months, from 1 May 1995 to 1 May 1996
Participants Number of participants: 113 enrolled
Inclusion criteria: age 1 to 12 months; acute watery diarrhoea; presence of mild or moderate dehydration; weight for age > 80% of 50th centile
Exclusion criteria: newborn; presence of bloody diarrhoea; systemic illness; intake of antibiotics; severe dehydration; moderate to severe malnutrition
Interventions
  • Glucose ORS: 51 participants.

  • Rice ORS: 48 participants.

Outcomes
  • Total stool output in first 24 hours.

  • Duration of diarrhoea.

  • Number of participants with unscheduled use of intravenous fluid.

Glucose‐based ORS osmolarity ≤ 270 mOsm/L
Setting Paediatric clinic
Location: Ciuj‐Napoca, Romania
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk RCT: randomly assigned
Allocation concealment (selection bias) Unclear risk Not reported
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Participants, providers. and outcome assessors not blinded
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Participants, providers. and outcome assessors not blinded
Incomplete outcome data (attrition bias) 
 All outcomes High risk The trial included only 88% of the randomized participants in the analysis
Selective reporting (reporting bias) High risk The trial reported only 88% of the included participants in the final analysis
Other bias Unclear risk We did not detect any other sources of bias