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Inhibitory effects of the novel triazole bisphosphonates on prenyl synthases and prenyl transferases.
| GGDPS IC50 (μM) | FDPS IC50 (μM) | FTase IC50 (μM) | GGTase I IC50 (μM) | |
|---|---|---|---|---|
| 17a (bishomoprenyl) | 3.6 ± 2.4 | >100 | >100 | >100 |
| 17b (bishomogeranyl) | 2.6 ± 0.5 | 33.3 ± 6.7 | >100 | >100 |
| 17c (bishomoneryl) | 1.3 ± 0.2 | 29.8 ± 5.5 | >100 | >100 |
