Figure 1.

Modeling human blood flow and thrombus formation dynamics within a multi-bypass ladder network. Parameters of a multi-bypass microfluidic ladder network device design (a) and an experimental prototype as visualized by differential interference contrast (DIC) microscopy (b). Network features two main channels and ten bypasses (bp 1–10); micrograph shows the first four bypasses. Black bars indicate a stoppered inlet and outlet; red arrows depict the direction of blood flow. Stoppered inlets and outlets were re-opened during the washing step.