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. Author manuscript; available in PMC: 2018 Mar 21.
Published in final edited form as: Biochemistry. 2017 Mar 7;56(11):1645–1655. doi: 10.1021/acs.biochem.7b00020

Figure 8.

Figure 8

Cartoon models of MRJP1/apisimin complexes. (a) A+G+ conditions favor (MRJP14 apisimin4) assemblies; apisimin acts as a hydrophobic linker that connects the relatively structured MRJP1 C-terminal regions. The N-terminal regions are disordered. Apisimin-depleted samples (b) A−G+ and (c) A−G− form (MRJP12 apisimin1) complexes. (d) A+G− samples undergo apisimin-mediated formation of soluble aggregates. MRJP1 is colored light blue. Apisimin is colored dark purple. Glycans at N144 and N177 are colored red. The hydrophobic MRJP1 segment of residues 316–322 is colored yellow.