Figure 2.
PaO2/FiO2 ratios and compliance values derived from C57BL/6 and RAGE −/−mice 4–24 hours after TBI. (A) PaO2/FiO2 ratios from controls without TBI and wildtype mice 4–24 hours after TBI. (B) Static compliance values obtained via Pulmonary Function Testing from controls without TBI and wildtype mice 4–24 hours after TBI. (C) PaO2/FiO2 ratios from C57BL/6 and RAGE−/− 24 hours after TBI. Animals were administered either moderate or severe TBI. (D) Compliance values from controls and C57BL/6 and RAGE −/− mice 24 hours after TBI. n=4–7 mice per condition, comparisons versus sham-injured group unless otherwise indicated, *p<0.01 Statistical testing included unpaired t-tests and analysis of variance.