PaO2/FiO2 ratios and compliance values 24 hours after TBI in RAGE −/−, TLR4 −/− mice treated with HMGB1 neutralizing antibody, and mice treated with TAT-4BB decoy peptide. (A) PaO2/FiO2 ratios in control mice and RAGE −/−, TLR4 −/− mice treated with HMGB1 antibody or control antibody, or treated with 4BB (Myd-88) decoy peptide 24 hours after TBI. (B) Compliance values in RAGE −/−, TLR4 −/− mice treated with HMGB1 antibody or control antibody, or with 4BB decoy peptide 24 hours after TBI. n=5–7 per condition, comparisons versus sham-injured group unless otherwise indicated, *p≤0.01. Statistical testing included unpaired t-tests and analysis of variance.