Figure 4.
Histology and acute lung injury scores for transplanted left lungs from control donor mice, wildtype TBI donor mice, or RAGE−/− TBI donor mice. Representative H/E histology sections from transplanted lungs 5 days after transplant. (A) Transplanted left lung from healthy donor with sham TBI. (B) Transplanted left lung from wildtype TBI donor. (C) Transplanted left lung from RAGE−/− TBI donor. (D) Acute lung injury scores from transplant recipients who received lungs from three different donors: wildtype animals with sham TBI, wildtype animals with TBI, and RAGE −/− donors with TBI. n=6–8 per condition, comparison versus sham-injured group, *p<0.01. Statistical testing included unpaired t-tests and analysis of variance