Skip to main content
. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Alzheimers Dis. 2017;56(4):1469–1484. doi: 10.3233/JAD-160869

Fig. 2.

Fig. 2

Effect of treadmill exercise on STZ-induced hippocampal neuronal degeneration. A) Representative confocal pictures of rat hippocampal pyramidal CA1 neurons from control, STZ, STZ + Exe groups stained with the neuronal marker, NeuN and the neurodegenerative marker, F-Jade C, indicating robust neuron loss and neuronal degeneration following STZ insult, which was significantly attenuated by treadmill exercise. Scale bar = 20 μm. B) Quantification analysis was performed by counting surviving neurons and F–Jade C-positive neurons. The results indicate that neuronal loss and acute neuronal degeneration were induced by STZ administration at early stage of AD progression, whereas treadmill exercise exerted significant neuroprotection by increasing neuronal survival and decreasing neurodegeneration. n = 8 per group. Values are means ± SE. *p < 0.05 versus normal control; #p < 0.05 versus STZ group.