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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Alzheimers Dis. 2017;56(4):1469–1484. doi: 10.3233/JAD-160869

Fig. 5.

Fig. 5

Treadmill exercise ameliorates STZ-induced oxidative stress damage. A) Western blot analysis of reactive nitrogen species (RNS) generation, marked by 3-NT. STZ-induced RNS accumulation was markedly attenuated by treadmill exercise during AD progression. B) Confocal analysis for oxidative stress-induced damage to basic cellular components: lipid, histone and DNA, marked by 4-HNE (a–c), P-H2A.X (d–f), and 8-OHDG (g–i) respectively. Note that treadmill exercise significantly attenuated STZ-induced cellular oxidative damages. C) Relative immunoreactivity was analyzed in a diagram form following the confocal analysis above, with data expressed as fold changes versus normal control. Scale bar = 20 μm. n = 5 per group. Values are means ± SE. *p < 0.05 versus normal control; #p < 0.05 versus STZ group.