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. 2012 Oct 15;186(8):752–762. doi: 10.1164/rccm.201202-0302OC

Figure 5.

Figure 5.

Bleomycin induced severe pulmonary fibrosis in matrix metalloproteinase (Mmp)19-deficient mice. (A–F) Light micrographs in the lung sections from Mmp19−/− and WT mice. (A, B) Wild-type (WT) mice, 21 days after saline or bleomycin instillation, stained with hematoxylin and eosin (10×). (C) WT mice, 21 days after bleomycin (40×). (D, E) MMP19−/− mice, 21 days after saline or bleomycin instillation, stained with hematoxylin and eosin (10×). (F) Mmp19−/− mice, 21 days after bleomycin (40×). (G, H) Immunostaining of αSMA in the lung sections from Mmp19−/− and WT mice; samples were counterstained with hematoxylin (10×). Inset: positive fibroblasts in a fibroblast focus (40×). Bottom: lung hydroxyproline levels in Mmp19−/− and their WT littermates after bleomycin; results represent mean ± SD from six knockout and WT mice; *P < 0.05.