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. 2017 May 31;12(5):e0177454. doi: 10.1371/journal.pone.0177454

Fig 1. Orco antagonist activity of phenylthiophenecarboxamide compounds OX1t-OX1w.

Fig 1

Compounds were initially screened at 100 μM against ORs from Drosophila melanogaster (Dmel\Orco+Dmel\OR35a activated by 10 μM OLC12) and Culex quinquefasciatus (Cqui\Orco+Cqui\OR21 activated by 3 μM OLC12). Concentration-inhibition curves were constructed for compounds that displayed favorable antagonist activity at both receptors. OX1a (a previously identified Orco antagonist [49]) served as a reference compound. Data are presented as mean ± SEM (n = 3–11). nd, not determined.