Table 4. GEE logistic regression for BKPyV reactivation.
| Variable | OR | 95% CI | P | OR | 95% CI | P |
|---|---|---|---|---|---|---|
| Univariable Analysis | Multivariable Analysis | |||||
| Month | 1.08 | 1.02–1.13 | <0.01 | |||
| MMF Dose | 0.99 | 0.99–0.99 | 0.01 | |||
| Recipient CMV Status | 3.65 | 0.77–17.28 | 0.10 | |||
| Recipient Race | 0.31 | 0.07–1.48 | 0.14 | |||
| Donor Race | 0.19 | 0.02–1.53 | 0.12 | |||
| Cause of Renal Failure | 0.48 | 0.24–0.95 | 0.03 | 0.44 | 0.19–0.99 | <0.05 |
| Anti BKPyV IgG | 3.98 | 1.77–8.93 | <0.01 | 4.01 | 1.54–10.46 | <0.01 |
| Per % CD4 IFN-γ+ T-Cells | 1.05 | 1.01–1.10 | 0.03 | |||
| Per % CD8 IFN-γ+ T-Cells | 1.08 | 1.01–1.15 | 0.03 | |||
| Per % CD3+ T-Cells | 0.98 | 0.97–1.00 | 0.03 | |||
| Per % CD8+ T-Cells | 1.04 | 1.01–1.06 | <0.01 | 1.04 | 1.00–1.07 | <0.05 |
| Per % CD4+ T-Cells | 0.94 | 0.91–0.96 | <0.01 | 0.95 | 0.92–0.98 | <0.01 |
OR = Odds Ratio. CI = Confidence Interval. Percent CD3+ T-Cells, CD4+ T-Cells and CD8+ T-Cells are the percent of peripheral blood mononuclear cells (PBMC) which are CD3+ (T-Cells), CD4+ or CD8+ respectively. Percent CD4 IFN-γ+ and Percent CD8+ IFN-γ+ T-Cells are the percent of cultured PBMC which secrete interferon gamma in response to BKPyV antigen stimulation. Cause of Renal Failure, see Table 1. MMF = mycophenolate mofetil.