Table 4. Gene ages.
(A) Phylogenetic age groups in million years ago (MYA) retrieved from the Ensembl (release 75) gene trees. (B) Essential versus viable mouse genes frequencies for different MRD+SCA age groups. (C) Essential versus viable mouse genes frequencies for different DCA+SCA age groups. These results are observed for the non-culled dataset. Here, the Bonferroni corrected p-value in the Chi-squared test is 0.003125.
| A | B | C | |||||
|---|---|---|---|---|---|---|---|
| Taxon or Age Group | Age (MYA) | Essential (%) | Viable (%) | p-value | Essential (%) | Viable (%) | p-value |
| Murinae | 25 | 0.63 | 2.17 | 3.7×10−4 | 0.16 | 0.36 | 0.27 |
| Rodentia | 77 | 0.00 | 0.09 | 0.286 | 0.00 | 0.00 | 0 |
| Sciurognathi | 78 | 0.00 | 0.06 | 0.383 | 0.00 | 0.00 | 0 |
| Glires | 86 | 0.24 | 0.06 | 0.104 | 0.00 | 0.00 | 0 |
| Euarchontoglires | 92 | 0.55 | 0.51 | 0.858 | 0.00 | 0.00 | 0 |
| Eutheria | 104 | 11.60 | 11.23 | 0.737 | 0.39 | 1.36 | 4.5×10−3 |
| Theria | 162 | 1.25 | 2.80 | 2.3×10−3 | 0.31 | 1.24 | 4.2×10−3 |
| Mammalia | 167 | 3.45 | 5.03 | 0.025 | 0.39 | 1.13 | 0.019 |
| Amniota | 296 | 5.41 | 4.79 | 0.403 | 0.70 | 2.10 | 1.1×10−3 |
| Tetrapoda | 371 | 1.41 | 2.56 | 0.020 | 0.16 | 1.13 | 1.4×10−3 |
| Euteleostomi | 400 | 31.58 | 41.69 | 8.3×10−7 | 10.34 | 16.58 | 7.8×10−7 |
| Sarcopterygii | 414 | 1.80 | 2.74 | 0.070 | 0.00 | 1.36 | 2.9×10−5 |
| Vertebrata | 535 | 13.48 | 14.80 | 0.290 | 10.42 | 14.51 | 6.5×10−4 |
| Chordata | 722 | 4.00 | 3.25 | 0.219 | 5.60 | 7.94 | 8.3×10−3 |
| Bilateria | 937 | 15.67 | 6.08 | 4.8×10−23 | 52.72 | 41.01 | 7.8×10−8 |
| Opisthokonta | 1215 | 8.93 | 2.14 | 6.6×10−25 | 18.82 | 11.28 | 3.1×10−10 |