Table 7. Differences in the frequencies of different enzyme class observed between essential and viable mouse proteins.

The Bonferroni corrected p-valu for the Chi-squared tests is 0.0083.

Datasets		Enzyme Classes
		Oxidoreductase	Transferase	Hydrolase	Lyase	Isomerase	Ligase
Non-culled	Essential	3.4	13.5	8.1	1.31	0.69	2.9
	Viable	3.7	10.1	10.9	1.10	0.67	1.2
	p-value	0.59	1.81×10−3	5.88×10−3	0.56	0.92	5.43×10−5
Culled (20%)	Essential	6.05	12.94	10.02	2.92	1.46	2.92
	Viable	6.00	9.64	12.59	1.18	1.38	1.28
	p-value	0.97	0.068	0.18	0.017	0.90	0.027
Culled (40%)	Essential	3.95	13.42	9.26	1.77	0.94	3.23
	Viable	4.17	9.30	11.56	1.26	0.83	1.26
	p-value	0.781	9.2×10−4	0.070	0.26	0.75	1.6×10−4
Culled (60%)	Essential	3.46	13.83	8.07	1.40	0.74	3.13
	Viable	3.77	9.53	11.59	1.16	0.71	1.19
	p-value	0.63	1.1×10−4	1.4×10−3	0.52	0.91	1.4×10−5
Culled (80%)	Essential	3.41	13.56	7.90	1.32	0.70	2.94
	Viable	3.77	10.06	11.03	1.12	0.68	1.21
	p-value	0.56	1.3×10−3	2.7×10−3	0.58	0.94	4.5×10−5