Table 12. Subcellular locations of all essential and viable mouse proteins as annotated in the UniProt database.
p–values were computed using the Chi–square test. Here, the Bonferroni corrected p-value = 0.0041.
| Cellular Components | Essential | Viable | %Essential | %Viable | p-value |
|---|---|---|---|---|---|
| Nucleus | 627 | 815 | 48.2 | 23.6 | 8.37×10−43 |
| Cytoplasm | 433 | 1014 | 33.3 | 29.4 | 0.030 |
| Plasma membrane | 170 | 805 | 13.1 | 23.3 | 3.4×10−12 |
| Membrane (excluding plasma) | 117 | 545 | 9.0 | 15.8 | 2.2×10−8 |
| Extracellular | 95 | 504 | 7.3 | 14.6 | 2.6×10−10 |
| Mitochondrion | 67 | 145 | 5.1 | 4.2 | 0.17 |
| Endoplasmic Reticulum (ER) | 70 | 192 | 5.4 | 5.6 | 0.81 |
| Golgi | 62 | 150 | 4.8 | 4.3 | 0.54 |
| Lysosome | 10 | 80 | 0.8 | 2.3 | 5.4×10−4 |
| Peroxisome | 5 | 22 | 0.4 | 0.6 | 0.30 |
| Cell Junction | 78 | 199 | 6.0 | 5.8 | 0.77 |
| Cell Projection | 47 | 130 | 3.6 | 3.8 | 0.81 |