Table 18. Key domains from the Pfam database that are enriched in proteins encoded by essential mouse genes.
| Term ID | Term Annotation | Count | % | Bonferroni Corrected p-Value |
|---|---|---|---|---|
| PF00046 | Homeobox domain | 63 | 4.9 | 1.8x10-17 |
| PF00010 | Helix-loop-helix DNA-binding domain | 28 | 2.2 | 4.7x10-7 |
| PF07714 | Protein tyrosine kinase | 29 | 2.2 | 5.0x10-5 |
| PF00110 | Wnt family | 11 | 0.9 | 8.7x10-5 |
| PF00907 | T-box | 10 | 0.8 | 3.7x10-4 |
| PF00008 | EGF-like domain | 19 | 1.5 | 7.1x10-4 |
| PF00105 | Zinc finger, C4 type (two domains) | 14 | 1.1 | 7.6x10-3 |
| PF00688 | TGF-beta propeptide | 10 | 0.8 | 8.7x10-3 |
| PF00104 | Ligand-binding domain of nuclear hormone receptor | 14 | 1.1 | 0.012 |
| PF00019 | Transforming growth factor beta like domain | 12 | 0.9 | 0.018 |
| PF00069 | Protein kinase domain | 49 | 3.8 | 0.019 |