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. 2017 May 31;12(5):e0178273. doi: 10.1371/journal.pone.0178273

Table 19. Key domains from the Pfam database that are enriched in proteins encoded by viable mouse genes.

Term ID Term Annotation Count % Bonferroni Corrected p-Value
PF00001 7 transmembrane receptor (rhodopsin family) 162 4.7 4.2x10-41
PF00017 SH2 domain 56 1.6 2.2x10-14
PF07714 Protein tyrosine kinase 65 1.9 1.1x10-12
PF00520 Ion transport protein 53 1.5 2.6x10-10
PF00018 SH3 domain 49 1.4 2.4x10-8
PF00069 Protein kinase domain 121 3.5 4.8x10-8
PF00104 Ligand-binding domain of nuclear hormone receptor 28 0.8 4.1x10-6
PF13895 Immunoglobulin domain 32 0.9 6.5x10-6
PF00105 Zinc finger, C4 type (two domains) 26 0.8 4.2x10-5
PF10613 Ligated ion channel L-glutamate- and glycine-binding site 15 0.4 5.6x10-5
PF00060 Ligand-gated ion channel 15 0.4 5.6x10-5
PF01582 TIR domain 16 0.5 1.2x10-4
PF00211 Adenylate and Guanylate cyclase catalytic domain 16 0.5 1.2x10-4
PF00619 Caspase recruitment domain 17 0.5 1.9x10-4
PF02931 Neurotransmitter-gated ion-channel ligand binding domain 23 0.7 4.1x10-4
PF02932 Neurotransmitter-gated ion-channel transmembrane region 23 0.7 4.1x10-4
PF00229 TNF(Tumour Necrosis Factor) family 14 0.4 7.6x10-4
PF00020 TNFR/NGFR cysteine-rich region 15 0.4 1.2x10-3
PF00041 Fibronectin type III domain 49 1.4 1.3x10-3
PF00045 Hemopexin 16 0.5 1.7x10-3
PF00102 Protein-tyrosine phosphatase 21 0.6 2.2x10-3
PF00433 Protein kinase C terminal domain 18 0.5 2.3x10-3
PF00595 PDZ domain (Also known as DHR or GLGF) 45 1.3 5.2x10-3
PF00413 Matrixin 15 0.4 6.2x10-3
PF01471 Putative peptidoglycan binding domain 14 0.4 0.011
PF00005 ABC transporter 24 0.7 0.014
PF00019 Transforming growth factor beta like domain 19 0.6 0.019
PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) 24 0.7 0.021
PF00230 Major intrinsic protein 10 0.3 0.031
PF00664 ABC transporter transmembrane region 14 0.4 0.042